T cells in CLL

Ramsay et al¹ unravel a new mechanism of immune subversion induced by chronic lymphocytic leukemia (CLL) cells to perturb chemokine-oriented migration of both CD4⁺ and CD8⁺ T cells, and they propose an original cereblon-dependent effect of the immunomodulatory drug lenalidomide.

CLL cells induce adhesion and migration defects in T cells that are reversible upon lenalidomide treatment.

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T cells in CLL: lost in migration

Source: Blood

Art and Science of Laboratory Medicine

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