Researchers Identify New Mechanism of TB Drug Resistance

Pyrazinamide (PZA) -- a frontline tuberculosis (TB) drug -- kills dormant persister bacteria and plays a critical role in shortening TB therapy. PZA is used for treating both drug-susceptible and multi-drug-resistant TB (MDR-TB) but resistance to PZA occurs frequently and can compromise treatment.

A recent study, led by researchers at the Johns Hopkins Bloomberg School of Public Health and Huashan Hospital, Fudan University, has identified a new mechanism for PZA-resistance, which provides new insight into the how this mysterious drug works. The study is available online June 12 in the journal Emerging Microbes and Infections.


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Researchers Identify New Mechanism of TB Drug Resistance

Source: Advanced


Art and Science of Laboratory Medicine

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