Lot-to-lot Variations in Immunoassay Testing

Lot-to-lot variation in immunoassay testing is one of the most common quality control (QC) issues faced by laboratory professionals. If not managed effectively, shifts in QC following a reagent lot change can be a significant source of analytical errors for laboratories.
This can be especially so when very low concentrations of an analyte are being reported as clinically significant or when a reference range is very narrow. A good example is provided by the measurement of troponin in the diagnosis of myocardial infarction. Demands for more reliable and faster tests to detect heart attacks have driven the diagnostic industry to produce more sensitive assays.

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Lot-to-lot Variations in Immunoassay Testing 

Source: ADVANCE
Image credits: Marina Karakaltsas and Joe Vincini

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