New insights into HIV impact on hematopoiesis

Patients with long-term HIV infection often exhibit multiple hematopoietic syndromes that encompass anemia, granulocytopenia, and thrombocytopenia, suggesting a central deficiency in hematopoiesis. A number of previous studies attempted to delineate the mechanism by which these conditions ensue. However, clear understanding of the impairment mechanism(s) remained an intractable problem because of the paucity of studies using a suitable experimental animal model that closely recapitulates human hematopoiesis during an ongoing HIV infection in vivo. 

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New insights into HIV impact on hematopoiesis

Source: Blood
Image credits: Debra T. Dartez

Art and Science of Laboratory Medicine

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