An endocrinologist contacted our laboratory to report a patient with discordant TSH results: undetectable TSH by our routine assay, the Siemens ADVIA Centaur TSH3-UL, and normal TSH by an alternate TSH assay, the Abbott Architect. The clinical picture of the patient matched the normal results. We ruled out common interferences and ran the sample on a total of eight FDA-approved TSH immunoassays. Four of these assays, all from Siemens, were unable to detect the TSH in the sample while four others, from Siemens, Beckman, Abbott and Roche, all detected TSH at similar concentrations.
Read more:
Four Commonly Utilized Immunoassays Fail to Detect TSH in a Cohort of Euthyroid Patients: Are TSH Assays Hyper-Selective?
Source:AACC
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Koi Health
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