Lymphoproliferative disorder with Auer rod–like inclusions

The patient is a 92-year-old woman who presented to the hematology clinic 3 years earlier for evaluation of persistent lymphocytosis. At that time, her white blood cell count was 15 200/µL, hemoglobin was 12.8 g/dL, and platelets were 245 000/µL. Her absolute lymphocyte count was 7870/µL. She did not have lymphadenopathy or hepatosplenomegaly on physical examination.

This case highlights a rare example where the presence of Auer rod–like inclusions does not automatically denote myeloid differentiation. To the best of our knowledge, the presence of Auer rod–like lymphocyte inclusions has been previously reported only in a single case of a peripheralizing marginal zone lymphoma from Japan.

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Lymphoproliferative disorder with Auer rod–like inclusions

Source: Blood Journal