An Infant with Persistent Jaundice and a Normal Newborn Direct Bilirubin

A 54-day-old infant of Asian descent presented with jaundice. He first started appearing yellow a few weeks after birth. His pediatrician initially recommended increasing sunlight exposure. At subsequent visits, the pediatrician recommended stopping breastfeeding. Despite these interventions, the infant's jaundice persisted and his stools became pale. At 52 days of life (DoL), he had a serum bilirubin measured, and the reported “Bilirubin, Direct” concentration of 5.54 mg/dL (reference interval, 0.0–0.4 mg/dL) prompted an immediate referral (see Table 1 for a summary of laboratory results).

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An Infant with Persistent Jaundice and a Normal Newborn Direct Bilirubin Measurement

Source: Clinical Chemistry