Isatin - Possible stress marker in blood

A research collaboration between the universities of Oslo and Aarhus has resulted in the development of a new method with diagnostic potential. The new method that combines phase extraction with an enzymatic reaction may eventually be used for an improved and faster screening analysis of isatin as a potential indicator of stress and neurological disorders.

Isatin is a small organic molecule found in low concentrations in different tissues and is excreted with the urine via the blood stream. Isatin is supposedly a degradation product from the neurotransmitters, e.g. dopamine and serotonine. The level of isatin is elevated in patients suffering from stress and in patients suffering from Parkinson’s disease. The level of isatin is also elevated among pregnant women.

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Method for determining possible stress marker in blood samples

 Source: Aarhus University