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i heart histo
Source: I Heart Histo
Art and Science of Laboratory Medicine
Showing posts with label pathology. Show all posts
Showing posts with label pathology. Show all posts
Sunday, January 22, 2017
Sunday, December 25, 2016
Thursday, December 8, 2016
Study indicates a genetic test may show which chemotherapy patients are at risk for serious blood clots
Chemotherapy is known to carry a risk of venous thromboembolism in cancer patients, a particularly common risk in frequent cancers like breast cancer. But a genetic test may predict which of these patients are most likely to develop such serious blood clots, researchers report.
VTE is preventable through prophylaxis treatment with heparin, an anticoagulant. But because a side effect is less controllable bleeding, the drug is not routinely recommended to patients undergoing chemotherapy.
Researchers examined 4,261 Swedish women diagnosed with primary invasive breast cancer between 2001 and 2008. Risk stratification was based on chemotherapy use and genetic susceptibility, which was determined by a risk score assessing nine genes involved in VTE. Patients ranked in the highest 5 percent were classified as having a high genetic susceptibility.
Patients were followed for a median of 7.6 years, and 276 experienced a VTE during that time.
Read more:
Blood Clot Risk in Breast Cancer Patients Seen via Gene Test
Source: Breast cancer news
VTE is preventable through prophylaxis treatment with heparin, an anticoagulant. But because a side effect is less controllable bleeding, the drug is not routinely recommended to patients undergoing chemotherapy.
Researchers examined 4,261 Swedish women diagnosed with primary invasive breast cancer between 2001 and 2008. Risk stratification was based on chemotherapy use and genetic susceptibility, which was determined by a risk score assessing nine genes involved in VTE. Patients ranked in the highest 5 percent were classified as having a high genetic susceptibility.
Patients were followed for a median of 7.6 years, and 276 experienced a VTE during that time.
Read more:
Blood Clot Risk in Breast Cancer Patients Seen via Gene Test
Sunday, December 4, 2016
Science Coloring Book
Thermo Fisher Scientific Beautiful Science Cell Imaging Colouring Book and Felt-Tip Marker Set.
Colour your way through 30 incredibly beautiful organic patterns inspired by actual cell images submitted by researchers around the world. True to the broad spectrum of cells and their complex structures, the pages include fantastically illustrated representations of tissues, plasma membranes, cytoskeletons, nuclei and everything in-between.
Complete the form below to download a copy of the Colouring Book now or check the box below to request a hard copy to be sent to you with a set of felt-tip markers and join millions of adults all around the world who are rediscovering the relaxation and bliss of colouring.
Get your coloring book here:
Color the achievements of your colleagues and have fun doing it
Source: Thermo Fisher Scientific
Colour your way through 30 incredibly beautiful organic patterns inspired by actual cell images submitted by researchers around the world. True to the broad spectrum of cells and their complex structures, the pages include fantastically illustrated representations of tissues, plasma membranes, cytoskeletons, nuclei and everything in-between.
Complete the form below to download a copy of the Colouring Book now or check the box below to request a hard copy to be sent to you with a set of felt-tip markers and join millions of adults all around the world who are rediscovering the relaxation and bliss of colouring.
Get your coloring book here:
Color the achievements of your colleagues and have fun doing it
From path with love
Amasing histology slide
Original image:
Good morning
Source: Facebook via Trust me I´m a "Medical Technologist"
Original image:
Good morning
Sunday, November 20, 2016
Saturday, November 5, 2016
CML Cookies
Beautiful blood cell cookies by Kristine Krafts
Here we have a neutrophilic leukocytosis with a left shift (there’s a myelocyte, top left, a metamyelocyte, bottom left, and a promyelocyte, center) and a basophilia (right). Check out how mature the chromatin is in the myelocyte, metamyelocyte, and segmented neutrophil – but how fine it is (you can even see nucleoli!) in the promyelocyte). Also, the granules in the promyelocyte are in the cytoplasm and over the nucleus as well. The basophil granules are kinda obscuring the nucleus, but that’s what happens in real life, so we’ll call it artistic rendering.
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Blood cookies! - Pathology student
Source: Pathology student
Image credits: Kristine Krafts, M.D.
Here we have a neutrophilic leukocytosis with a left shift (there’s a myelocyte, top left, a metamyelocyte, bottom left, and a promyelocyte, center) and a basophilia (right). Check out how mature the chromatin is in the myelocyte, metamyelocyte, and segmented neutrophil – but how fine it is (you can even see nucleoli!) in the promyelocyte). Also, the granules in the promyelocyte are in the cytoplasm and over the nucleus as well. The basophil granules are kinda obscuring the nucleus, but that’s what happens in real life, so we’ll call it artistic rendering.
Read more
Blood cookies! - Pathology student
Image credits: Kristine Krafts, M.D.
Monday, September 5, 2016
Scientists have finally figured out how cancer spreads through the bloodstream
In what could be a major step forward in our understanding of how cancer moves around the body, researchers have observed the spread of cancer cells from the initial tumour to the bloodstream.
The findings suggest that secondary growths called metastases 'punch' their way through the walls of small blood vessels by targeting a molecule known as Death Receptor 6 (no, really, that's what it's called). This then sets off a self-destruct process in the blood vessels, allowing the cancer to spread.
According to the team from Goethe University Frankfurt and the Max Planck Institute in Germany, disabling Death Receptor 6 (DR6) may effectively block the spread of cancerous cells - so long as there aren't alternative ways for the cancer to access the bloodstream.
Read more:
Scientists have finally figured out how cancer spreads through the bloodstream
Source: ScienceAlert
Image: K. Hodivala-Dilke, M. Stone/Wellcome Images
The findings suggest that secondary growths called metastases 'punch' their way through the walls of small blood vessels by targeting a molecule known as Death Receptor 6 (no, really, that's what it's called). This then sets off a self-destruct process in the blood vessels, allowing the cancer to spread.
According to the team from Goethe University Frankfurt and the Max Planck Institute in Germany, disabling Death Receptor 6 (DR6) may effectively block the spread of cancerous cells - so long as there aren't alternative ways for the cancer to access the bloodstream.
Read more:
Scientists have finally figured out how cancer spreads through the bloodstream
Image: K. Hodivala-Dilke, M. Stone/Wellcome Images
Monday, August 22, 2016
A variant of hairy cell leukemia
Case: A 63-year-old woman being followed for splenomegaly presented with lymphocytosis (hemoglobin, 14 g/dL; neutrophils, 2.5 × 109/L; lymphocytes, 8.5 × 109/L; monocytes, 0.7 × 109/L; platelets, 200 × 109/L). A blood smear showed 40% medium-sized lymphocytes with abundant cytoplasm with circumferential projections, similar to those of classic hairy cells. The nucleus had condensed chromatin with a conspicuous nucleolus (panels A-F). Flow cytometry revealed 45% clonal B lymphocytes that expressed CD19/CD20/CD22/CD103/CD11c and a lack of CD5/CD10/CD123/CD25/CD200. The BRAFV600E mutation was negative, confirming the diagnosis of hairy cell leukemia-variant (HCL-v).
Read more:
Lymphocytosis, villi, and nucleoli: a variant of hairy cell leukemia
Source: Blood journal
Image: ASH Image Bank
Read more:
Lymphocytosis, villi, and nucleoli: a variant of hairy cell leukemia
Image: ASH Image Bank
Friday, August 19, 2016
Free Online Atlas of Genetics in Haematology
The Atlas of Genetics and Cytogenetics in Oncology and Haematology is a peer reviewed on-line journal, encyclopaedia and database in free access on the Internet, devoted to genes, cytogenetics, and clinical entities in cancer, and cancer-prone diseases.
The aim is to cover the entire field under study. It presents structured reviews (cards) or traditional review papers ('deep insights'), a portal towards genetics and/or cancer databases and journals, teaching items in Genetics for students in Medicine and in Sciences, and a case report in hematology section.
It is made for and by: clinicians and researchers in cytogenetics, molecular biology, oncology, haematology, and pathology. Contributions are reviewed before acceptance. It deals with cancer research and genomics. It is at the crossroads of research, virtual medical university (university and post-university e-learning), and telemedicine. It contributes to "meta-medicine", this mediation, using new information technology, between the increasing amount of knowledge and the individual, having to use the information. Towards a personalized medicine of cancer.
Open Atlas here:
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Source: atlasgeneticsoncology.org
The aim is to cover the entire field under study. It presents structured reviews (cards) or traditional review papers ('deep insights'), a portal towards genetics and/or cancer databases and journals, teaching items in Genetics for students in Medicine and in Sciences, and a case report in hematology section.
It is made for and by: clinicians and researchers in cytogenetics, molecular biology, oncology, haematology, and pathology. Contributions are reviewed before acceptance. It deals with cancer research and genomics. It is at the crossroads of research, virtual medical university (university and post-university e-learning), and telemedicine. It contributes to "meta-medicine", this mediation, using new information technology, between the increasing amount of knowledge and the individual, having to use the information. Towards a personalized medicine of cancer.
Open Atlas here:
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wednesday, May 11, 2016
Sunday, March 13, 2016
Scientists identify a virus and two bacteria that could be causing Alzheimer's
An international group of 31 Alzheimer's researchers has published an
editorial urging the science world to change its focus when it comes to
Alzheimer's disease. The message is clear - after a decade of failed
attempts to treat and prevent the disease, it's time to reassess the
evidence that Alzheimer's could be spread by microbes.
Study says that the first microbes we should investigate are the herpes simplex virus type 1 (HSV1), the chlamydia bacteria, and spirochaetes.
So how could viruses and bacteria trigger Alzheimer's disease? Well, we still don't really know, which is one of the reasons research has stalled in this area, but the herpes virus is already known to damage the nervous system, and microbial infections are known to inflammation around the body, which is a characteristic of Alzheimer's disease.
Of course, the issue is not as clear-cut as the editorial makes it out to be - if it was, we'd already know how to fix the disease. And most importantly, experts are urging people not to freak out about the implication that Alzheimer's could be 'caught'.
Read more:
Scientists identify a virus and two bacteria that could be causing Alzheimer's
Source: ScienceAlert
Study says that the first microbes we should investigate are the herpes simplex virus type 1 (HSV1), the chlamydia bacteria, and spirochaetes.
So how could viruses and bacteria trigger Alzheimer's disease? Well, we still don't really know, which is one of the reasons research has stalled in this area, but the herpes virus is already known to damage the nervous system, and microbial infections are known to inflammation around the body, which is a characteristic of Alzheimer's disease.
Of course, the issue is not as clear-cut as the editorial makes it out to be - if it was, we'd already know how to fix the disease. And most importantly, experts are urging people not to freak out about the implication that Alzheimer's could be 'caught'.
Read more:
Scientists identify a virus and two bacteria that could be causing Alzheimer's
Saturday, March 5, 2016
Histology Zoo
Incidental Findings in your Reproductive Organs
by i♡histo
A rooster from prostata, a dolphin from placenta, a whale from breast and a swan from cervix.
Read more.
i heart histo
Source: i hert histo
by i♡histo
A rooster from prostata, a dolphin from placenta, a whale from breast and a swan from cervix.
Read more.
i heart histo
Source: i hert histo
Friday, February 26, 2016
Understanding the role of human polyomaviruses in cancer
Human polyomaviruses are commonly found in the population and generallydo not produce noticeable symptoms. However, one type of human polyomavirus, the Merkel cell polyomavirus, is known to cause a rare form of skin cancer called Merkel cell carcinoma, and other members of the polyomavirus family can induce non-cancer related diseases in people with compromised immune systems. To determine whether other members of the polyomavirus might be associated with cancer development, Yuan Chang and colleagues at the University of Pittsburgh Medical Center developed a new method to screen tumor samples for the presence of any human polyomavirus. As reported in this month's issue of JCI Insight, the researcher's screening protocol relied on a cocktail of antibodies that can recognize a specific protein expressed by all polyomaviruses.
They screened over 1,000 tumor samples, including cases of lung carcinoma, bladder carcinoma, brain tumors, colon cancer, breast cancer, and malignant melanoma. Their study found no evidence for the involvement of human polyomaviruses in the development of these cancers and helps to resolve questions in the field about whether viruses related to Merkel cell polyomavirus contribute to cancer. Their technique will also be valuable in studying other diseases in which polyomaviruses are suspected to play a role.
Read more:
Survey for human polyomaviruses in cancer
Source: JCL insight
They screened over 1,000 tumor samples, including cases of lung carcinoma, bladder carcinoma, brain tumors, colon cancer, breast cancer, and malignant melanoma. Their study found no evidence for the involvement of human polyomaviruses in the development of these cancers and helps to resolve questions in the field about whether viruses related to Merkel cell polyomavirus contribute to cancer. Their technique will also be valuable in studying other diseases in which polyomaviruses are suspected to play a role.
Read more:
Survey for human polyomaviruses in cancer
Tuesday, February 23, 2016
Flow Cytometry Finds Prostate Cancer
Flow cytometry is making it possible for researchers to detect prostate cancer with a single drop of blood.
Hon Leong, PhD, assistant professor at Western University’s Schulich School of Medicine and Dentistry and scientist at Lawson Health Research Institute, and his team have repurposed a machine once used to detect airborne pathogens in the second Gulf War. The machine is now used for fluid biopsies – a non-invasive way to detect prostate microparticles in the blood in a matter of minutes. Microparticles are essentially garbage released by prostate cells that circulate throughout the bloodstream.
Leong’s research provides a more accurate and less invasive testing method for patients suspected of having prostate cancer, and helps to identify patients who are at a higher risk of dying from prostate cancer.
“Our findings point to a new direction in how we can better identify patients who actually have prostate cancer,” said Leong. “With this test, we can improve the clinical outcomes for patients, reducing costs for unnecessary procedures and reducing errors in diagnosis.”
Read more:
Detecting prostate cancer with a drop of blood and Gulf War technology
Source: Media Relations
Hon Leong, PhD, assistant professor at Western University’s Schulich School of Medicine and Dentistry and scientist at Lawson Health Research Institute, and his team have repurposed a machine once used to detect airborne pathogens in the second Gulf War. The machine is now used for fluid biopsies – a non-invasive way to detect prostate microparticles in the blood in a matter of minutes. Microparticles are essentially garbage released by prostate cells that circulate throughout the bloodstream.
Leong’s research provides a more accurate and less invasive testing method for patients suspected of having prostate cancer, and helps to identify patients who are at a higher risk of dying from prostate cancer.
“Our findings point to a new direction in how we can better identify patients who actually have prostate cancer,” said Leong. “With this test, we can improve the clinical outcomes for patients, reducing costs for unnecessary procedures and reducing errors in diagnosis.”
Read more:
Detecting prostate cancer with a drop of blood and Gulf War technology
Monday, February 22, 2016
Lab Cat Screening
I just love mouse cytology
Source: Cranbrook Veterinary Hospital for Dogs and Cats, located in Cranbrook, BC.
Saturday, February 20, 2016
Tissue Theme
A perfect set of cups for a laboratory scientist working at histology lab.
Read more:
Histology Cup and Saucer
Source: Anatomy Boutique
Read more:
Histology Cup and Saucer
Monday, February 15, 2016
Progress in fighting cancer and infections with T cell therapy
The quest to bring immunotherapy into widespread clinical use against cancer and infectious diseases has made great strides in recent years. For example, clinical trials of adoptive T cell therapy are yielding highly promising results. The latest progress is being reported at the Annual Meeting of the American Association for the Advancement of Science.
T cell immunity has evolved to recognize and respond to health threats and provide a lifelong memory that prevents recurrent disease. However, with chronic diseases, reactive T cells often become inactive or even disappear. Recent advances have brought the idea of fighting chronic infections, and even cancers, by restoring protective T cell responses much closer to reality.
The main focus of the AAAS 2016 session "Fighting Cancer and Chronic Infections with T Cell Therapy: Promise and Progress" is on adoptive T cell therapy, in which a patient receives "killer" immune cells that target a disease-associated molecule. Several obstacles have stood in the way of widespread clinical use: identifying or generating T cells that will be most effective for each individual case, whether from the patient or from a suitable donor; avoiding or countering potential
side-effects; and finding ways to shorten the path from bench to bedside. Progress is being reported on all three fronts, including data from the first clinical trials.
Read more:
Progress in fighting cancer and infections with T cell therapy
Source: EurekAlert! Science News
T cell immunity has evolved to recognize and respond to health threats and provide a lifelong memory that prevents recurrent disease. However, with chronic diseases, reactive T cells often become inactive or even disappear. Recent advances have brought the idea of fighting chronic infections, and even cancers, by restoring protective T cell responses much closer to reality.
The main focus of the AAAS 2016 session "Fighting Cancer and Chronic Infections with T Cell Therapy: Promise and Progress" is on adoptive T cell therapy, in which a patient receives "killer" immune cells that target a disease-associated molecule. Several obstacles have stood in the way of widespread clinical use: identifying or generating T cells that will be most effective for each individual case, whether from the patient or from a suitable donor; avoiding or countering potential
side-effects; and finding ways to shorten the path from bench to bedside. Progress is being reported on all three fronts, including data from the first clinical trials.
Read more:
Progress in fighting cancer and infections with T cell therapy
Sunday, February 14, 2016
Wednesday, February 10, 2016
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