Neutrophil alphabet

Features of prominent Dohle bodies (letters N and S); cytoplasmic vacuolation (letters L, M, and W); and toxic granulation (letters I and S) represent toxic changes consistent with reactive neutrophilia secondary to acute pneumonia. Atypical nuclear segmentation generated a complete modern English alphabet and is a result of accelerated neutrophil maturation. 

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Neutrophil alphabet

Source: Blood


Art and Science of Laboratory Medicine

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