Total analytic error vs. total error

"My friends and colleagues Jim and Sten Westgard have written an article about total analytical error in which I am mentioned." Their article says that total analytical error (TAE) is important and estimated by the equation TAE=average bias + 2xSD. They later go on to say that higher multiples of the SD are useful for Six Sigma methods.

So what are the problems?

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Total analytical error vs. total error 

Source: Krouwer Consulting
Image credits: jkrouwer

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