BSA-GFR in patients with a BSA <1.60 m2 overestimated GFR with a bias of 10.08 ml/min (11.46%) and underestimated GFR in those with a BSA >2 m2 with a bias up to −20.76 ml/min (−23.59%). BSA is not a good normalization index (NI) in patients with extreme body sizes. Therefore, until a better NI is found, we recommend clinicians to use the absolute GFR to calculate individual drug chemotherapy dosage as well as express individual kidney function.
Indexing Glomerular Filtration Rate to Body Surface Area: Clinical Consequences
Source: Journal of Clinical Laboratory Analysis
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