Art and Science of Laboratory Medicine

Art and Science of Laboratory Medicine

Tuesday, August 23, 2016

Sepsis - How can a hematology laboratory help?

Sepsis, the inflammatory response to infection, is quickly becoming one of the biggest healthcare problems worldwide. No matter the perspective one takes, the numbers are staggering. Currently the number of diagnosed cases per year in the United States is at least 750,000; some estimates surpass one million. Worldwide mortality estimates are as high as 20 percent, and thus we are dealing with one of the biggest drivers of mortality in modern medicine. Sepsis kills nearly as many people as heart attack, HIV, and breast cancer combined.

An “upgraded” CBC-diff results can be used as early warning biomarkers even before clinical suspicion would justify the ordering of more costly tests such as procalcitonin.
For these reasons, researchers have recently published numerous studies on new strategies to leverage already available CBC-diff data for early detection of sepsis. These strategies fall in two broad categories: multi-parametric algorithms, and utilization of cellular morphologic data.
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Sepsis and the hematology laboratory 

Source: MLO

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