Art and Science of Laboratory Medicine. Clinical laboratory and biomedical science related news, abstracts and images for medical laboratory professionals, students and other laboratory geeks.
Art and Science of Laboratory Medicine
Friday, October 25, 2013
Auer rod-like inclusions in κ light chain myeloma
A 56-year-old woman with a history of dyslipidemia and hepatic steatosis presented with weight loss and progressive proteinuria. The presenting blood count was normal: white blood cells, 10.9 × 109/L; hemoglobin, 15.5 g/dL; platelet count, 236 × 109/L. No significant rouleaux formations were present on the peripheral blood smear. Calcium (9.28 mg/dL), blood urea nitrogen/creatinine (15/0.78 mg/dL), and protein/albumin (6.9/4.2 g/dL) were normal. The squelettal survey showed no lytic bone lesions. Serum protein electrophoresis and immunofixation electrophoresis showed no monoclonal component. Serum-free light chain assay revealed high levels of κ light chains (890 mg/L) and normal levels of λ light chains (9.8); κ-λ ratio was 90.8. Urine protein electrophoresis showed free κ-type Bence-Jones proteinuria (1.64 g/L). A bone marrow aspiration revealed a normal blast count (3%) and no dysplasia. Plasma cells constituted 20% of nucleated cells.