Art and Science of Laboratory Medicine

Art and Science of Laboratory Medicine

Wednesday, April 10, 2013

Diagnosis of Bleeding Disorders

When screening for a blood disorder there are five basic tests:
  • Complete Blood Count (CBC) -- measures the amount of hemoglobin, red blood cells, white blood cells and platelets
  • Bleeding Time (surrogate PFA-100) -- measures basic platelet adhesion and aggregation
  • Prothrombin Time (PT) -- measures the clotting ability of extrinsic factors (I, II, V, VII and X)
  • Partial Thrombin Time (PTT) -- measures the clotting ability of intrinsic factors (VIII, IX, XI and XII)
  • Fibrinogen or Thrombin Time (TT) -- measures the level of fibrinogen activity and TT measures whether fibrinogen is inhibited
These tests suggest whether coagulation factor deficiency or thrombocytopenia might be the potential cause of clinical bleeding.
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Diagnosis of Bleeding Disorders




















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Art and Science of Laboratory Medicine

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2 comments:

Rødhette said...

If all those tests come up negative and the patient still have an increased bleeding tendency, one might want to consider if the patient has Ehlers Danlos Syndrome (EDS)!

RAWDA RUTH SARRAIL said...

* This method especially applicable for Neonates & Pedias. ~

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