State of the Art for Measurement of Urine Albumin

Urine albumin is the primary biomarker for detection and monitoring of kidney damage. Because fixed decision criteria are used to identify patients with increased values, we investigated if commonly used routine measurement procedures gave comparable results.

Bias is the dominant source of disagreement among routine measurement procedures. Consequently, standardization efforts are needed improve agreement among results. Variation of bias with concentration needs to be addressed by manufacturers.

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State of the Art for Measurement of Urine Albumin: Comparison of Routine Measurement Procedures to Isotope Dilution Tandem Mass Spectrometry

 Source: Clinical Chemistry