Art and Science of Laboratory Medicine

Art and Science of Laboratory Medicine

Monday, August 4, 2014

Haemolysis: a pre-analytical challenge in the lab

Haemolysis is defined as the release of haemoglobin and other intracellular components from erythrocytes, thrombocytes and leukocytes into the extracellular fluid i.e. the plasma or serum, following damage or disruption of cell membranes. Haemolysed specimen is the most common reason for rejection of specimens in the lab. Studies have shown that out of the total specimens received in the lab, 3.3% are found to be haemolysed, and out of the total rejected; 40-70% has been identified to be due to haemolysis. The American Society of Clinical Pathology has established a 2%, or lower, benchmark for haemolysis rates amongst laboratory blood samples.

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Haemolysis: a major challenge in the lab

Source: Medlab Magazine

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