Intrinsic and extrinsic anemias

When we use the words intrinsic and extrinsic in reference to anemias, we’re talking usually about the things that cause hemolytic anemias. Some hemolytic anemias are caused by things intrinsic to the red cell itself (like a problem with the red cell membrane, as is the case in hereditary spherocytosis, or a problem with a red cell enzyme, as is the case in G6PD deficiency) vs. things that are extrinsic to the red cell (like the fibrin strands that rip apart red cells in microangiopathic hemolytic anemia).

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Intrinsic vs. extrinsic anemias

Source: Pathology student