Art and Science of Laboratory Medicine

Art and Science of Laboratory Medicine

Monday, September 14, 2015

Microscope lamp

Vintage metal 1960's Porter microscope repurposed into a unique night light / lamp. Made by hand in New York City by Northern Electric Lighting Company, this is the perfect gift for the science nerd in all of us.

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REPURPOSED MICROSCOPE LAMP vintage antique

Source: via ETSY


Laboratory Rose

Serratia marcescens, Chromobacterium violeceum and Pseudomonas aeruginosa - what a romantic combination on Mueller Hinton II agar. All 3 organisms exhibit different pigment, Red, Purple and Green respectively on MHII agar, makes our daily routine of interpreting disk diffusion  more interesting.

Read more:
Lovely Rose - American Society for Microbiology


Sunday, September 13, 2015

Free eBook - Basic malaria microscopy

Microscopists are vital to malaria programmes, and their diagnostic and technical skills are relied on in both curative services and disease surveillance. Thus, training in malaria microscopy must be sound and must reach today’s high standards. When microscopists are trained and able to make quality-assured diagnoses of malaria, communities at risk have greater confidence in their services, and both patients and prescribers benefit.

'Read more:
WHO | Basic malaria microscopy – Part I: Learner's guide. Second edition

Source: WHO

Saturday, September 12, 2015

Friday, September 11, 2015

Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

CRISPR/Cas9 protein fused to transactivation domains can be used to control gene expression in human cells. In this study, we demonstrate that a dCas9 fusion with repeats of VP16 activator domains can efficiently activate human genes involved in pluripotency in various cell types. This activator in combination with guide RNAs targeted to the OCT4 promoter can be used to completely replace transgenic OCT4 in human cell reprogramming. Furthermore, we generated a chemically controllable dCas9 activator version by fusion with the dihydrofolate reductase (DHFR) destabilization domain. Finally, we show that the destabilized dCas9 activator can be used to control human pluripotent stem cell differentiation into endodermal lineages.

Read more:
Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation: Stem Cell Reports



Source: Stem cell reports

Thursday, September 3, 2015

The laboratorian´s way to say

I love you <3


Image credits: Polly Nikou

Creative Microbiology

Microbiology is as much a part of the universe as the Mandela represents. In a patient culture we focus on each component. Finding answers in a culture is both stimulating and relaxing. Using science and chemical reactions we get answers. Sometimes it's like solving a really hard puzzle. There are still a lot of bench tests that require skill and observation.


Read more:
AgarArt 2015

Source: Microbeworld
Image credits:
Diane Martin, Cooley Dickinson Hospital

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