Art and Science of Laboratory Medicine

Art and Science of Laboratory Medicine

Thursday, January 30, 2014

Lymphoid Malignancies - Flow cytometry can identify abnormal cell populations and identify clonal proliferations

Flow cytometry is an invaluable tool that can identify the presence of abnormal cell populations and aide in confirming the diagnosis of lymphocytic malignancies. Additionally, various types of lymphomas can be classified by the surface antigens expressed on the cells. Flow cytometric immunophenotyping demonstrates the immunologic features of the cells which classify the tumor. By correlating the results with clinical symptoms and other diagnostic findings, the physician can diagnose and treat the patient with the appropriate chemotherapy regimen.

The use of flow cytometry is essential in diagnosing lymphoid malignancies and can determine whether a clonal proliferation is B or T- cell in origin. Flow cytometry indentifies and quantitates cellular antigens with flurochrome-labeled monoclonal antibodies. This process is called immunophenotyping.

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Lymphoid Malignancies

Source: Advance

Image credits: Pathpedia

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