Asplenic patients are at risk for rapidly progressive septicemia and death. Such patients should be vaccinated against pneumococci, H. influenzae type b, meningococci, and influenza virus, and if fever develops, they should receive empirical antimicrobial therapy immediately.
Mortality among patients with postsplenectomy sepsis can be as high as 50%. Most commonly caused by Streptococcus pneumoniae, this infection often has a sudden onset and a fulminant course.
Care of the Asplenic Patient