Homozygous hemoglobin C disease

A 44-year-old African American female presented with a pain crisis and a history of hemoglobinopathy, menometrorrhagia secondary to acquired von Willebrand factor (vWF) deficiency, and a history of multiple vaso-occlusive events necessitating lifelong warfarin therapy. Further history revealed that she had four pain crises in the previous year requiring hospitalizations, multiple splenic infarcts with resultant autosplenectomy, one normal pregnancy with no preceding miscarriages, and no history of bone necrosis.

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Homozygous hemoglobin C disease

Source: Blood
Image credits: ASH Image Bank

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