Factors in the blood from calorie-restricted rats can modify energy-producing mitochondria within the insulin-producing cells that regulate blood sugar levels, new research shows. This has a positive impact on glucose-stimulated insulin secretion and protects cells from fatty acid and glucose toxicity.
The findings suggest that insulin-producing cells’ mitochondria may be altered by signals independent of the body’s fuel levels and may represent a useful therapeutic target in type 2 diabetes. Additionally, identifying these blood factors may open even more targetable interventions against the disease.
Factors in the Blood During Dieting May Have Anti-Diabetes Properties