Art and Science of Laboratory Medicine

Art and Science of Laboratory Medicine

Saturday, February 1, 2014

Treatment Discovered for Paroxysmal Nocturnal Hemoglobinemia

Paroxysmal nocturnal hemoglobinemia (PNH) is a rare form of cancer characterized by episodic rupture of red blood cells and the danger of blood clots forming in the vascular system. The condition results in red blood cells becoming vulnerable to attacks by the body's own complement immune system and can lead to complications such as anemia, kidney disease and fatal thromboses.

In a clinical study published today in PLOS ONE, the UBC team, led by Prof. Patrick McGeer, applied aurin tricarboxylic acid (ATA), a non-toxic drug, to blood samples of five patients with PNH who were undergoing standard treatment with antibodies administered through biweekly infusions.
The researchers found the addition of ATA restored blood cell resistance to complement system attacks, while the antibodies alone did not offer full protection.

Read more:
Treatment discovered for rare blood cancer  



Source: Science Daily
Image credits: Mahidol university


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