Art and Science of Laboratory Medicine

Art and Science of Laboratory Medicine

Saturday, July 19, 2014

Helicobacter pylori home in on small lesions

The ulcer-causing bacteria Helicobacter pylori swiftly swarm to sites of microscopic damage on the surface of the mouse stomach. The microbes accumulate at these injury sites within minutes, and can slow tissue repair. These are the earliest events in H. pylori pathogenesis reported in vivo, according to a study published July 17 in PLOS Pathogens.

Previous studies have shown that both motility and chemotaxis are crucial to H. pylori colonization in the stomach. Mutants that are unable to sense pH gradients or concentrations of chemicals such as urea, arginine, or carbon dioxide are less capable of causing ulcers, requiring several times more bacteria than wild-type strains. But how these properties helped the bacteria colonize damaged stomach tissue was not clear.

Read more:
Ulcer-forming Bacteria Target Tiny Traumas 

Source: TheScientist

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